Sermorelin: what the research shows
A short copy of the brain’s growth-hormone signal that was once a prescription medicine for children.
Also known as Geref
At a glance
Once approved in the US (as Geref) for children with growth hormone deficiency. It is no longer sold there as an approved medicine.
What is Sermorelin?
Sermorelin is the first 29 building blocks of growth-hormone-releasing hormone (GHRH), the part of the hormone that does the work.
How does Sermorelin work?
It tells the pituitary gland to release growth hormone in natural pulses, rather than replacing growth hormone directly.
What does the research show?
- It was used to test for, and treat, growth hormone deficiency in some children (1999 review).
Known risks and side effects
- Outside an approved product, quality and strength can vary.
- Common side effects in studies included reactions at the injection site.
Is Sermorelin approved?
It was once an approved medicine but is no longer sold as one.
Once approved in the US (as Geref) for children with growth hormone deficiency. It is no longer sold there as an approved medicine.
From the community
Watch: Sermorelin and related science
We have not selected a reliable dedicated Sermorelin video. These lessons cover the relevant biology and research methods; the compound-specific evidence is in the sources below.
khanacademymedicine
The hypothalamus and pituitary gland
How the hypothalamus and pituitary coordinate hormone release, including growth and reproductive hormones.
Khan Academy · endocrine physiology
Related biology
Background on hypothalamus and pituitary signalling for understanding Sermorelin. It does not demonstrate benefits of this compound or formulation.
American Association of Clinical Endocrinology
Patient guide to growth hormone deficiency
An overview of growth hormone deficiency and specialist care. It does not establish anti-ageing benefits or benefits of growth-hormone-releasing research peptides.
Professional endocrinology association
Related biology
Explains diagnosed growth hormone deficiency. This is different from claims about anti-ageing or unapproved growth-hormone-releasing compounds.
Ninja Nerd
Endocrinology: growth hormone
A detailed lesson on growth hormone physiology and its signalling pathways.
Medical physiology education
Related biology
Background on growth hormone physiology for understanding Sermorelin. It does not demonstrate benefits of this compound or formulation.
Sources and references
- Sermorelin: a review of its use in the diagnosis and treatment of children with idiopathic growth hormone deficiencyPrakash & Goa · BioDrugs · 1999
VETUD Learn explains published research in plain language. It is general information, not medical advice. Talk to a doctor before starting, stopping or changing any treatment.
In the research shop
Check the catalog for related laboratory research materials. These products are separate from the approved medicines and clinical trial formulations discussed here.
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