5-Amino-1MQ: what the research shows
Not a peptide: a small compound that blocks an enzyme linked to fat storage, studied in mice.
At a glance
Not approved. Studied in cells and mice.
This compound is not a peptide, but is often discussed alongside them.
What is 5-Amino-1MQ?
5-Amino-1MQ is a small chemical, not a peptide. It blocks NNMT, an enzyme that is especially active in fat tissue.
How does 5-Amino-1MQ work?
Blocking NNMT changes how fat cells use energy. In lab studies it reduced the making of new fat in fat cells.
What does the research show?
- In mice made obese by a high-fat diet, it reduced body weight and fat (2018 study).
- It has not been tested in people.
Known risks and side effects
- Its effects and safety in people are unknown.
Is 5-Amino-1MQ approved?
Mostly studied in cells and animals, with little or no proper testing in people.
Not approved. Studied in cells and mice.
From the community
Watch: 5-Amino-1MQ and related science
We have not selected a reliable dedicated 5-Amino-1MQ video. These lessons cover the relevant biology and research methods; the compound-specific evidence is in the sources below.
Khan Academy
Mitochondria: structure and cellular energy
A foundation for reading mitochondrial research. It does not demonstrate a benefit from any experimental compound.
Biology education
Related biology
Background on mitochondria and cellular energy for understanding 5-Amino-1MQ. It does not demonstrate benefits of this compound or formulation.
Progress, Potential, and Possibilities
NAD coenzymes, metabolic stress and new interventions
A leading NAD scientist on what the molecule does and what boosting it might achieve.
Interview with Charles Brenner, PhD, NAD researcher at City of Hope
Related biology
Background on NAD metabolism for understanding 5-Amino-1MQ. It does not demonstrate benefits of this compound or formulation.
Sources and references
- Selective and membrane-permeable small molecule inhibitors of nicotinamide N-methyltransferase reverse high fat diet-induced obesity in miceNeelakantan et al. · Biochemical Pharmacology · 2018
- Nicotinamide N-methyltransferase inhibition mitigates obesity-related metabolic dysfunctionBabula et al. · Diabetes, Obesity and Metabolism · 2024
VETUD Learn explains published research in plain language. It is general information, not medical advice. Talk to a doctor before starting, stopping or changing any treatment.
In the research shop
Check the catalog for related laboratory research materials. These products are separate from the approved medicines and clinical trial formulations discussed here.
Checking regional availability…
